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CAS No.: 196597-26-9
Synonyms: TAK-375;雷美替胺
Ramelteon is a synthetic melatonin analogue working by binding to and activating melatonin receptors 1 and 2.
生物活性
靶点 | MT Receptor 2 Ki:112pM | MT Receptor 1 Ki:14pM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00642694 | - | - | Terminated(Enrollment disconti... more >>nued based on mutually agreed upon decision by PI and funding sponsor) Collapse << | - | - |
NCT02969343 | Central Line-Associated Bloods... more >>tream Infection (CLABSI) Venous Thromboembolism Patient Fall Catheter-Associated Infection Severe Hypoglycemia Opioid-Related Severe Adverse Drug Event Hospital Acquired Pressure Ulcer Adverse Drug Event Severe Hospital Acquired Delerium Rapid Response Related to Arrhythmia Collapse << | Not Applicable | Recruiting | September 2018 | United States, Massachusetts ... more >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Alexandra C Businger 617-732-7063 abusinger@partners.org Contact: Patricia Dykes, RN PhD 617-732-8925 pdykes@partners.org Principal Investigator: David W Bates, MD MSc Collapse << |
NCT00893269 | Marijuana Dependence | Phase 1 | Completed | - | United States, Maryland ... more >> Johns Hopkins University Baltimore, Maryland, United States, 21224 Collapse << |
实验方案
技术信息
CAS号 | 196597-26-9 | 储存条件 |
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分子式 | C16H21NO2 | 运输 | 蓝冰 | |||||||||||||
分子量 | 259.34 | 别名 | TAK-375;雷美替胺 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00642694 | - | - | Terminated(Enrollment disconti... more >>nued based on mutually agreed upon decision by PI and funding sponsor) Collapse << | - | - |
NCT02969343 | Central Line-Associated Bloods... more >>tream Infection (CLABSI) Venous Thromboembolism Patient Fall Catheter-Associated Infection Severe Hypoglycemia Opioid-Related Severe Adverse Drug Event Hospital Acquired Pressure Ulcer Adverse Drug Event Severe Hospital Acquired Delerium Rapid Response Related to Arrhythmia Collapse << | Not Applicable | Recruiting | September 2018 | United States, Massachusetts ... more >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Alexandra C Businger 617-732-7063 abusinger@partners.org Contact: Patricia Dykes, RN PhD 617-732-8925 pdykes@partners.org Principal Investigator: David W Bates, MD MSc Collapse << |
NCT00893269 | Marijuana Dependence | Phase 1 | Completed | - | United States, Maryland ... more >> Johns Hopkins University Baltimore, Maryland, United States, 21224 Collapse << |
NCT03461042 | Chronic Insomnia | Phase 4 | Recruiting | January 31, 2019 | Japan ... more >> Yoyogi Sleep Disorder Clinic, Foundation of Sleep and Health Science Recruiting Shibuya-ku, Tokyo, Japan, 151-0053 Contact: Akira Usui, MD Collapse << |
NCT00337272 | Chronic Insomnia | Phase 4 | Terminated(Lack of enrollment.... more >>) Collapse << | - | United States, Arkansas ... more >> Genesis Cancer Center Hot Springs, Arkansas, United States, 71913 United States, California Wilshire Oncology Medical Group, Inc. La Verne, California, United States, 91750 United States, Connecticut Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut, United States, 06360 United States, Georgia Augusta Oncology Associates, PC Augusta, Georgia, United States, 30901 United States, Idaho North Idaho Cancer Center Coeur d'Alene, Idaho, United States, 83814 United States, Montana Hematology Oncology Centers of the Northern Rockies Billings, Montana, United States, 59101 United States, Ohio Tri-County Hematology & Oncology Associates Canton, Ohio, United States, 44718 United States, Pennsylvania Pottsville Cancer Center Pottsville, Pennsylvania, United States, 17901 United States, Tennessee The West Clinic Memphis, Tennessee, United States, 38120 United States, Virginia Cancer Specialists of Tidewater, Ltd. Chesapeake, Virginia, United States, 23320 Collapse << |
NCT00688025 | - | - | Completed | - | United States, Michigan ... more >> Henry Ford Hospital Sleep Disorders & Research Center Detroit, Michigan, United States, 48202 Collapse << |
NCT00576927 | Sleep Deprivation | Phase 4 | Completed | - | - |
NCT00337272 | - | - | Terminated(Lack of enrollment.... more >>) Collapse << | - | - |
NCT03432091 | - | - | Enrolling by invitation | July 31, 2019 | - |
NCT02156271 | - | - | Completed | - | - |
NCT00755508 | Sleep Initiation and Maintenan... more >>ce Disorders Collapse << | Phase 2 | Completed | - | - |
NCT00576927 | - | - | Completed | - | - |
NCT00739024 | - | - | Terminated(Recruitment slow an... more >>d administrative reasons) Collapse << | - | - |
NCT00319215 | Insomnia | Phase 1 | Completed | - | Netherlands ... more >> Utrecht Institute for Pharmaceutical Sciences Utrecht, Netherlands, 3584CA Collapse << |
NCT00739024 | Migraine Migr... more >>aine With Aura Migraine Without Aura Collapse << | Phase 2 | Terminated(Recruitment slow an... more >>d administrative reasons) Collapse << | - | United States, Washington ... more >> Swedish Pain and Headache Center Seattle, Washington, United States, 98104 Collapse << |
NCT00671190 | Sleep Disorder | Phase 2 | Completed | - | United States, Arkansas ... more >> Hot Springs, Arkansas, United States United States, California Los Angeles, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States United States, Georgia Atlanta, Georgia, United States Macon, Georgia, United States United States, Indiana Danville, Indiana, United States United States, Kansas Overland Park, Kansas, United States United States, Louisiana Metairie, Louisiana, United States United States, Maryland Chevy Chase, Maryland, United States United States, Nevada Las Vegas, Nevada, United States United States, Ohio Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States Collapse << |
NCT01207050 | Insomnia Brai... more >>n Injury Collapse << | Phase 4 | Unknown | December 2014 | United States, New Jersey ... more >> Kessler Foundation Research Center West Orange, New Jersey, United States, 07052 Collapse << |
NCT02156271 | Insomnia | Phase 4 | Completed | - | - |
NCT00552760 | - | - | Completed | - | - |
NCT01180855 | Insomnia | Phase 4 | Unknown | September 2010 | United States, Arizona ... more >> University of Arizona Sleep Research Laboratory Tucson, Arizona, United States, 85721 Collapse << |
NCT00552760 | Bipolar Disorder | Phase 4 | Completed | - | United States, Pennsylvania ... more >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Collapse << |
NCT00507546 | Insomnia Spin... more >>al Cord Injury Tetraplegia Sleep Disorders Collapse << | Phase 4 | Completed | - | United States, California ... more >> VA Palo Alto Health Care System Palo Alto, California, United States, 94304-1290 Collapse << |
NCT00502320 | - | - | Completed | - | - |
NCT00507546 | - | - | Completed | - | - |
NCT00502320 | Seasonal Affective Disorder | Phase 4 | Completed | - | United States, Pennsylvania ... more >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Collapse << |
NCT03075657 | Schizophrenia | Phase 4 | Completed | - | India ... more >> All India Institute of Medical Sciences (AIIMS) Bhubaneswar, Odisha, India, 751019 Collapse << |
NCT00593736 | Sleep Disorders, Circadian Rhy... more >>thm Collapse << | Phase 2 | Completed | - | - |
NCT02560324 | Tobacco Use Disorder | Phase 2 | Completed | - | United States, Pennsylvania ... more >> Center for Interdisciplinary Research on Nicotine Addiction, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00237497 | Balance | Phase 3 | Completed | - | United Kingdom ... more >> London, United Kingdom Collapse << |
NCT00745030 | REM Behavior Disorder ... more >> Parkinsonism Collapse << | Not Applicable | Terminated(Low subject recruit... more >>ment and enrollment.) Collapse << | - | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 Collapse << |
NCT00745030 | - | - | Terminated(Low subject recruit... more >>ment and enrollment.) Collapse << | - | - |
NCT00593736 | - | - | Completed | - | - |
NCT00492011 | Circadian Dysregulation | Phase 4 | Completed | - | United States, Florida ... more >> Miami, Florida, United States Pembroke Pines, Florida, United States United States, Hawaii Honolulu, Hawaii, United States United States, New York New York, New York, United States Collapse << |
NCT00492232 | Chronic Insomnia | Phase 4 | Completed | - | - |
NCT00492232 | - | - | Completed | - | - |
NCT00671125 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00755495 | Sleep Initiation and Maintenan... more >>ce Disorders Collapse << | Phase 2 | Completed | - | - |
NCT00811746 | Obstructive Sleep Apnea | Not Applicable | Completed | - | United States, California ... more >> VA Long Beach Healthcare System Long Beach, California, United States, 90822-5201 Collapse << |
NCT00539110 | Sleep Burns | Phase 2 | Completed | - | United States, Ohio ... more >> Shriners Hospital for Children Cincinnati, Ohio, United States, 45229 Collapse << |
NCT00642694 | Major Depressive Disorder ... more >> Insomnia Collapse << | Phase 3 | Terminated(Enrollment disconti... more >>nued based on mutually agreed upon decision by PI and funding sponsor) Collapse << | - | United States, Texas ... more >> University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 752390-9119 Collapse << |
NCT00671255 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00325728 | Chronic Insomnia | Phase 2 | Completed | - | - |
NCT00671567 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT02691013 | Delirium Slee... more >>p Deprivation Collapse << | Not Applicable | Enrolling by invitation | December 31, 2018 | - |
NCT00907595 | Huntington's Disease ... more >> Parkinson's Disease Dementia With Lewy Bodies Sleep Disorders Circadian Dysregulation Collapse << | Not Applicable | Withdrawn(unable to recruit su... more >>bjects for study.Collaborator stopped funding for study as of 3/31/2010) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02144 Collapse << |
NCT00671398 | Transient Insomnia | Phase 3 | Completed | - | United States, California ... more >> Palm Springs, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Pembroke Pines, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, New York New York, New York, United States Rochester, New York, United States United States, Ohio Cincinnati, Ohio, United States Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States United States, Texas Houston, Texas, United States Collapse << |
NCT01401413 | REM Sleep Behavior Disorder | Phase 4 | Completed | - | United States, New York ... more >> Sleep Medicine Centers of WNY West Seneca, New York, United States, 14224 Collapse << |
NCT00539110 | - | - | Completed | - | - |
NCT00622427 | ADHD With Sleep Onset Insomnia | Phase 4 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35205 Collapse << |
NCT00622427 | - | - | Completed | - | - |
NCT00671294 | Chronic Insomnia | Phase 3 | Completed | - | United States, Arkansas ... more >> Hot Springs,, Arkansas, United States United States, California Irvine, California, United States Palm Springs, California, United States San Diego, California, United States United States, Florida Brandon, Florida, United States Miami, Florida, United States Naples, Florida, United States Pembroke Pines, Florida, United States St. Petersburg, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, Kentucky Crestview Hills, Kentucky, United States United States, Michigan Troy, Michigan, United States United States, Missouri St. Louis, Missouri, United States United States, North Carolina Winston-Salem, North Carolina, United States United States, Ohio Cincinnati, Ohio, United States Toledo, Ohio, United States United States, Texas Houston, Texas, United States Collapse << |
NCT00414102 | Chronic Insomnia | Phase 4 | Completed | - | - |
NCT00672724 | Chronic Insomnia | Phase 3 | Terminated(Issues with data co... more >>llection tool) Collapse << | - | - |
NCT00585208 | Insomnia Bipo... more >>lar Disorder Collapse << | Phase 3 | Terminated(sponsor terminated ... more >>study) Collapse << | - | United States, Ohio ... more >> The Lindner Center of HOPE Mason, Ohio, United States, 45040 Collapse << |
NCT00656994 | Insomnia | Phase 3 | Completed | - | - |
NCT00756002 | Sleep Initiation and Maintenan... more >>ce Disorders Collapse << | Phase 3 | Completed | - | - |
NCT00756002 | - | - | Completed | - | - |
NCT00672802 | Chronic Obstructive Pulmonary ... more >>Disease COPD Collapse << | Phase 2 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States United States, California Santa Monica, California, United States United States, Florida Miami Beach, Florida, United States Winter Park, Florida, United States United States, Kentucky Louisville, Kentucky, United States United States, Ohio Cincinnati, Ohio, United States Collapse << |
NCT00672061 | Sleep Apnea, Obstructive | Phase 2 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States United States, California Palm Springs, California, United States Santa Monica, California, United States United States, Florida Winter Park, Florida, United States United States, Ohio Cincinnati, Ohio, United States Collapse << |
NCT02324153 | Delirium Deli... more >>rium, Dementia, Amnestic, Cognitive Disorders Delayed Emergence From Anesthesia Cognitive Disorders Collapse << | Phase 2 | Recruiting | June 30, 2019 | United States, Maryland ... more >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21224 Contact: Kori Kindbom, MA 410-550-0197 kindbom@jhmi.edu Contact: Karin J Neufeld, MD MPH 410-550-0197 kneufel2@jhmi.edu Collapse << |
NCT00595075 | Healthy | Not Applicable | Completed | - | - |
NCT00671086 | Sleep Initiation and Maintenan... more >>ce Disorders Collapse << | Phase 3 | Completed | - | - |
NCT00869167 | Insomnia Asth... more >>ma Collapse << | Phase 3 | Terminated | - | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 Collapse << |
NCT00247390 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00316992 | Chronic Obstructive Pulmonary ... more >>Disease Collapse << | Phase 4 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States, 35213 United States, California Los Angeles, California, United States Santa Monica, California, United States, 90404 United States, Florida Naples, Florida, United States, 34110 St. Petersburg, Florida, United States, 33707 United States, Kentucky Louisville, Kentucky, United States, 40217 United States, Nebraska Lincoln, Nebraska, United States, 68510 United States, New York New York, New York, United States, 10025 Collapse << |
NCT00869167 | - | - | Terminated | - | - |
NCT00462254 | Parkinson's Disease | Phase 4 | Terminated(Study discontinued.... more >>) Collapse << | - | United States, California ... more >> VA Long Beach Healthcare System Long Beach, California, United States, 90822 Collapse << |
NCT00568789 | Insomnia | Phase 4 | Completed | - | United States, California ... more >> Costa Mesa, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Miramar, Florida, United States Orlando, Florida, United States United States, New York New York, New York, United States Collapse << |
NCT00595075 | - | - | Completed | - | - |
NCT00746239 | - | - | Terminated(Funding for continu... more >>ation was not received.) Collapse << | - | - |
NCT00595504 | Schizophrenia ... more >> Schizoaffective Disorder Schizophreniform Disorders Collapse << | Phase 4 | Completed | - | United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse << |
NCT00391755 | Migraine Headache | Phase 4 | Terminated(Failure to recruit ... more >>necessary number of patients.) Collapse << | - | United States, Virginia ... more >> Patricia Shipley, MD Charlottesville, Virginia, United States, 22902 Collapse << |
NCT00915135 | Chronic Insomnia | Phase 2 | Completed | - | - |
NCT00746239 | Panic Disorder ... more >> Insomnia Collapse << | Not Applicable | Terminated(Funding for continu... more >>ation was not received.) Collapse << | - | United States, Pennsylvania ... more >> Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Collapse << |
NCT00671632 | Drug Abuse | Phase 2 | Completed | - | United States, Maryland ... more >> Baltimore, Maryland, United States Collapse << |
NCT00753623 | Neuropathic Pain | Not Applicable | Terminated(Recruitment did not... more >> accrue as expected.) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT01467713 | Bipolar Disorder | Phase 3 | Terminated(Business Decision; ... more >>No Safety Concerns.) Collapse << | - | - |
NCT01467713 | - | - | Terminated(Business Decision; ... more >>No Safety Concerns.) Collapse << | - | - |
NCT01685151 | Bipolar Disorder | Phase 3 | Withdrawn(Business Decision (p... more >>lease see below)) Collapse << | November 2015 | - |
NCT01048242 | Insomnia Obst... more >>ructive Sleep Apnea Collapse << | Phase 3 | Completed | - | United States, Pennsylvania ... more >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00595504 | - | - | Completed | - | - |
NCT00753623 | - | - | Terminated(Recruitment did not... more >> accrue as expected.) Collapse << | - | - |
NCT01048242 | - | - | Completed | - | - |
NCT00914862 | - | - | Completed | - | - |
NCT00914862 | Insomnia | Phase 1 | Completed | - | United States, Kansas ... more >> Overland Park, Kansas, United States United States, Michigan Kalamazoo, Michigan, United States Collapse << |
NCT02153086 | - | - | Completed | - | - |
NCT01467700 | - | - | Terminated(Business Decision; ... more >>No Safety Concerns) Collapse << | - | - |
NCT02564939 | Delirium | Phase 4 | Recruiting | June 2019 | United States, Connecticut ... more >> Hartford Hospital Recruiting Hartford, Connecticut, United States, 06102 Contact: Robert S Dicks, MD 860-545-7043 robert.dicks@hhchealth.org Contact: Christine Waszynski, DNP 860-545-7043 christine.waszynski@hhchealth.org Collapse << |
NCT01467700 | Acute Depressive Episode | Phase 3 | Terminated(Business Decision; ... more >>No Safety Concerns) Collapse << | - | - |
NCT02058992 | - | - | Completed | - | - |
NCT03265951 | Insomnia | Phase 4 | Recruiting | June 30, 2020 | United States, New York ... more >> Veterans Affairs Medical Center in Buffalo Recruiting Buffalo, New York, United States, 14215 Contact: Ali El-Solh, MD, MPH 716-862-8622 solh@buffalo.edu Collapse << |
NCT02058992 | - | - | Completed | - | - |
NCT02153086 | - | - | Completed | - | Japan ... more >> Osaka, Japan Tokyo, Japan Collapse << |
NCT01677182 | Bipolar Disorder | Phase 3 | Terminated(Business Decision; ... more >>Terminated due to futility, with no safety concerns (see below)) Collapse << | - | - |
NCT01128582 | Gastroesophageal Reflux Diseas... more >>e Chronic Insomnia Collapse << | Phase 3 | Unknown | December 2011 | United States, Arizona ... more >> Southern Arizona Veterans Health Care System Tucson, Arizona, United States, 85723 Collapse << |
NCT03165695 | Delirium in Old Age | Phase 4 | Not yet recruiting | December 31, 2018 | United States, Massachusetts ... more >> Brigham and Women's Hospital Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Elizabeth B Klerman, M.D.,PhD 617-331-4580 ebklerman@research.bwh.harvard.edu Collapse << |
NCT01677182 | - | - | Terminated(Business Decision; ... more >>Terminated due to futility, with no safety concerns (see below)) Collapse << | - | - |
NCT03091738 | Cirrhosis | Phase 4 | Completed | - | United States, Virginia ... more >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Collapse << |
NCT02840591 | Delirium | Phase 4 | Withdrawn(Stopped the study du... more >>e to feasibility issues, no enrollment has taken place.) Collapse << | - | United States, Texas ... more >> The University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 Collapse << |
NCT02669082 | Insomnia Majo... more >>r Depressive Disorder Collapse << | Phase 4 | Completed | - | Japan ... more >> You Ariyoshi Sleep Clinic Kitakyushu, Fukuoka, Japan Ishikawa Mental Clinic Sapporo, Hokkaido, Japan Minami 1jo Mental Clinic Sapporo, Hokkaido, Japan Senzoku Psychosomatic Clinic Meguro, Tokyo, Japan Sangenjaya Neurology and Psychosomatic Clinic Setagaya, Tokyo, Japan Himorogi Kokorono Clinic Shinjuku, Tokyo, Japan Seiwa Hospital Shinjuku, Tokyo, Japan Collapse << |
靶点 | Description | IC50 |
---|---|---|
MT Receptor 2 | Ki:112pM | |
MT Receptor 1 | Ki:14pM |
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